Allenolic acid
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| Identifiers | |
|---|---|
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| CAS Number | 553-39-9 |
| PubChem (CID) | 96227 |
| ChemSpider | 86868 |
| UNII | I2MQT1CC3H |
| ChEBI | CHEBI:34529 |
| Chemical and physical data | |
| Formula | C13H12O3 |
| Molar mass | 216.23258 g/mol |
| 3D model (Jmol) | Interactive image |
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Allenolic acid, or allenoic acid, is a synthetic,[1] non-steroidal estrogen discovered in 1947 or 1948 that, although studied clinically,[2] was never marketed.[3][4][5] It is an open-ring or seco analogue of steroidal estrogens like estrone and equilenin.[6][7][8] The compound was named after Edgar Allen, one of the pioneers in estrogen research.[9][10] The methyl ether of allenolic acid, methallenestril (brand name Vallestril), is also an estrogen and, in contrast to allenolic acid, has been marketed.[11][12][13][14]
See also
References
- ↑ Rodolfo Paoletti; N. Pasetto; J.L. Ambrus (6 December 2012). The Menopause and Postmenopause: The Proceedings of an International Symposium held in Rome, June 1979. Springer Science & Business Media. pp. 110–. ISBN 978-94-011-7230-1.
- ↑ American Practitioner and Digest of Treatment. Lippincott. January 1951. p. 443.
- ↑ William J. Rea; Kalpana Patel (18 June 2010). Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 1: Regulating Mechanisms of Chemical Sensitivity. CRC Press. pp. 464–. ISBN 978-1-4398-1345-4.
- ↑ Geynet, C.; Millet, C.; Truong, H.; Baulieu, E.E. (1972). "Estrogens and Antiestrogens". Gynecologic and Obstetric Investigation. 3 (1-4): 1–29. doi:10.1159/000301742. ISSN 1423-002X.
- ↑ Furuya, Hiroshi; Deguchi, Keiji; Shima, Motowo (1957). "Experimental and clinical studies on a new synthetic estrogen, an allenolic acid derivative, vallestril". American Journal of Obstetrics and Gynecology. 74 (3): 635–650. doi:10.1016/0002-9378(57)90519-7. ISSN 0002-9378.
- ↑ Indian Journal of Chemistry: Organic including medicinal. Council of Scientific & Industrial Research. 1980. p. 886.
- ↑ Paul Ghalioungui; Ahmed Ghareeb (1963). Endocrines, Vitamins, and Some Common Metabolic Disorders. Dar al-Maaref. p. 194.
- ↑ James D. Morrison (November 1983). Stereodifferentiating addition reactions. Academic Press. p. v. ISBN 978-0-12-507702-6.
- ↑ Willard Owen Thompson (1953). The Year Book of Endocrinology. Year Book Medical Publishers. p. 292.
- ↑ American Practitioner and Digest of Treatment. Lippincott. January 1956.
- ↑ Journal of the Japanese Obstetrical & Gynecological Society. 1958. p. 83.
- ↑ Erich Heftmann (1970). Steroid Biochemistry. Academic Press. p. 144.
- ↑ The Effects of the Sulfonylureas and Related Compounds in Experimental and Clinical Diabetes. The Academy. 1957. p. 681.
- ↑ Alan C. Sartorelli; David G. Johns (27 November 2013). Antineoplastic and Immunosuppressive Agents. Springer Science & Business Media. pp. 106–. ISBN 978-3-642-65806-8.
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