API5
| API5 | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | API5, AAC-11, AAC11, apoptosis inhibitor 5 | ||||||||||||||||
| External IDs | MGI: 1888993 HomoloGene: 4809 GeneCards: API5 | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 11: 43.31 – 43.34 Mb | Chr 2: 94.41 – 94.44 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
| Wikidata | |||||||||||||||||
| View/Edit Human | View/Edit Mouse |
The human gene API5 encodes the protein Apoptosis inhibitor 5.[3][4]
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs.
Diseases associated with API5 include colon adenocarcinoma, and cervical cancer.
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (Oct 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Res. 57 (18): 4063–9. PMID 9307294.
- ↑ "Entrez Gene: API5 apoptosis inhibitor 5".
Further reading
- Gianfrancesco F, Esposito T, Ciccodicola A, et al. (1999). "Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene.". Cytogenet. Cell Genet. 84 (3-4): 164–6. doi:10.1159/000015247. PMID 10393420.
- Kim JW, Cho HS, Kim JH, et al. (2000). "AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis.". Lab. Invest. 80 (4): 587–94. doi:10.1038/labinvest.3780008. PMID 10780674.
- Van den Berghe L, Laurell H, Huez I, et al. (2001). "FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2.". Mol. Endocrinol. 14 (11): 1709–24. doi:10.1210/me.14.11.1709. PMID 11075807.
- Sutherland HG, Mumford GK, Newton K, et al. (2001). "Large-scale identification of mammalian proteins localized to nuclear sub-compartments.". Hum. Mol. Genet. 10 (18): 1995–2011. doi:10.1093/hmg/10.18.1995. PMID 11555636.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241
. PMID 12477932. - Li Z, Hu CY, Mo BQ, et al. (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng. 22 (4): 380–4. PMID 12703993.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Morris EJ, Michaud WA, Ji JY, et al. (2006). "Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo.". PLoS Genet. 2 (11): e196. doi:10.1371/journal.pgen.0020196. PMC 1636698. PMID 17112319.
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